Advances in Cryo-EM Structures of Key ABC and SLC Transport Proteins: Mechanistic and Functional Insights
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Over the past two decades, technological advances in membrane protein structural biology have provided insight into the molecular mechanisms that transporters use to move diverse substrates across the membrane. However, the plasticity of these proteins' ligand binding pockets, which allows them to bind a range of substrates, also poses a challenge for drug development. The structure, function, and transport mechanism of ATP-binding cassette (ABC)/solute carrier (SLC) transporters that are related to several diseases and multidrug resistance will be highlighted in this talk. ABC and SLC transporters play vital roles in clinical therapeutic outcomes. This talk will describe the current understanding of the structure of pharmacologically relevant transporters and how they interact with their ligands.
John Schuetz, Ph.D.
St. Jude Children's Research Hospital
John D. Schuetz received his Ph.D. from the Medical College of Virginia-Virginia/Virgina Commonwealth University with Robert Diasio (his lab identified the genetic basis of DPD deficiency); and conducted postdoctoral training with I. David Goldman (an SLC19A focused lab) and then wirh Philip Guzelian (identified Cyp3) cloned CYP3A5 and 7 at the same institution. He joined St. Jude Children’s Research Hospital as an Assistant Member (1992). He is a Member and former Vice Chair (2005-2022) of the Pharmaceutical Sciences Department. His lab reveals how transporters contribute to pathophysiology, drug response, and metabolism and has defined and functionally “deorphaned” transporters: ABCB6, ABCG2, and ABCC4 with over 175 articles in peerreviewed journals. He was nominated to membership in ASBMB. He is an Associate Editor for Pharmacological Reviews, Drug Resistance Updates, Drug Metabolism and Disposition and serves on the editorial boards of other journals. He was elected to the AAAS Electorate nominating committee and recently chair of the AAAS Pharmaceutical Sciences section S, elected Chair of the Toxicology Division of American Society for Pharmacology and Experimental Therapeutics (ASPET), Councilor and then ASPET’s President and nominated as an ASPET Fellow.
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