Mathematical Models to Characterize the Absorption, Distribution, Metabolism, and Excretion of Protein Therapeutics | Dr. Dhaval Shah
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This presentation provides an overview of mechanistic PK models developed to characterize ADME properties of therapeutic proteins (TPs), which can be used to support model-informed discovery and development of TPs. As the next-generation of TPs with diverse physicochemical properties and mechanism-of-action is being developed rapidly, there is an urgent need to better understand the determinants for the ADME of TPs and evolve existing platform PK models to facilitate successful bench-to-bedside translation of these promising drug molecules.
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Mathematical Models to Characterize the Absorption, Distribution, Metabolism, and Excretion of Protein Therapeutics
03/21/2023 at 11:00 AM (EDT) | Recorded On: 03/21/2023
03/21/2023 at 11:00 AM (EDT) | Recorded On: 03/21/2023
This presentation provides an overview of mechanistic PK models developed to characterize ADME properties of therapeutic proteins (TPs), which can be used to support model-informed discovery and development of TPs. As the next-generation of TPs with diverse physicochemical properties and mechanism-of-action is being developed rapidly, there is an urgent need to better understand the determinants for the ADME of TPs and evolve existing platform PK models to facilitate successful bench-to-bedside translation of these promising drug molecules.