Novel Tools and Methodologies to Study the Structure, Function, and Regulation of SLC Transporters | Alina Meyer, Colleen Yi, and Dr. Tongyi Dou

This webinar aims to introduce various tools/platforms, the use of primary human hepatocyte spheroids, cryo-electron microscopy, and bioengineered microRNA, in drug transporter research and drug discovery. The webinar also aims to recognize graduate students and postdoctoral fellows from academia who carried out transporter-related research and presented their work in the form of a poster at the 2022 ISSX/MDO International Meeting.

This webinar will feature three presentations and help scientists better understand:
1) the utility of using 3D primary human hepatocyte spheroids to study hepatic transporters
2) application of bioengineered microRNA in regulation of solute carrier (SLC) transporters
3) the structures of organic cation transporters revealed by electronic microscopy which help understand substrate or inhibitor binding with transporters.