PBPK Modelling for Predicting Disposition and Interactions of Drugs in Ethnic Populations

Physiologically based pharmacokinetic (PBPK) modelling is an approach that utilizes the knowledge of the physiological and biological elements of the human or animal body, otherwise known as “systems data”, to predict the PK of drugs when used in conjunction with relevant compound or drug data. This involves model development of both the compound and the population of interest in a suitable PBPK platform.

Ethnic variabilities can sometimes affect the outcome of drug pharmacokinetics and drug-drug interactions in different populations, and it is therefore important to consider the different sources of variability in PBPK model building. This talk will highlight the importance of demographic information in population model development, how the pharmacogenomics of polymorphic enzymes and transporters can differ between various ethnic populations, and how these translate to pharmacokinetic differences in the predicted disposition of drugs across ethnic populations.