Proteomic and Transcriptomic Analyses of Placental SLC and ABC Transporters and Implications for Fetal Drug Exposure--A Transporter Elucidation Network (TEN) Presentation
Includes a Live Web Event on 07/29/2026 at 3:00 PM (EDT)
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Placental ATP binding cassette (ABC) and solute carrier (SLC) transporters regulate the transfer of nutrients, endogenous compounds, drugs and metabolites between mother and fetus, impacting fetal development and pregnancy outcomes. Identification and accurate quantification of these transporters is critical for predicting nutrient and drug disposition and assessing drug safety throughout pregnancy. Proteomics and transcriptomics offer complementary strategies for identifying and quantifying transporter abundance in placental tissue of varying gestational age.
The key focus of the NIH‑funded Transporter Elucidation Network (TEN) aims to identify, quantify, and characterize SLC and ABC transporters in the human placenta, the lactating mammary gland, developing gut, and blood-brain barrier. This webinar will focus on the placenta and feature investigators from the University of Washington Transporter Elucidation Center (UWTEC) and the Integrated Transporter Elucidation Center (InTEC), two of the four Centers that comprise the NIH TEN.
The webinar will begin with proteomic approaches, both targeted and untargeted, and how they offer complementary strategies for identifying and quantifying transporter abundance in placental tissue. The webinar will then describe newly identified gestational age associated changes in nutrient transporter expression, novel associations between maternal and infant factors, including environmental chemical exposures, and ABC and SLC transporter enrichment in over 250 placentas from the US-based Understanding Pregnancy Signals and Infant Development (UPSIDE) cohort. Finally, transcriptomic analyses defining the spatial and temporal landscapes of SLC and ABC mRNA expression in human placentas will be presented and discussed.
Together, this webinar aims to advance understanding of SLC and ABC transporters in fetal nutrient and xenobiotic exposure and highlight emerging technologies that are transforming our ability to characterize placental transporters and their implications for fetal exposure to nutrients and medications.
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Jaqueline Tiley
Assistant Professor
University of North Carolina at Chapel Hill
Jacqueline B. Tiley, PhD, is an Assistant Professor in the Division of Pharmacotherapy and Experimental Therapeutics at the UNC Eshelman School of Pharmacy. She obtained her MSc in Pharmacy and PhD from the University of Basel in Switzerland. Dr. Tiley completed her postdoctoral training at the University of North Carolina at Chapel Hill. Her research program focuses on disease- and drug-mediated alterations in hepatic and placental transport proteins and its impact on drug disposition and toxicity.
Joanne Wang
Professor
University of Washington
Dr. Joanne Wang is a Professor of Pharmaceutics at the University of Washington School of Pharmacy in Seattle. She earned her PhD in Pharmaceutical Chemistry and completed postdoctoral training at the University of California, San Francisco. Her research focuses on membrane transporters and their roles in xenobiotic and nutrient disposition, pharmacokinetics, and drug-induced toxicity. Her current work examines placental transporters in fetal nutrient uptake and drug exposure and applies systems pharmacology and PBPK modeling to predict transporter-mediated drug exposure during pregnancy and lactation.
Samuel Arnold
Assistant Professor
University of Washington
Dr. Samuel Arnold joined the Department of Pharmaceutics at the University of Washington as an Assistant Professor in 2023, and his research predominantly focuses on characterizing exposure-response relationships for therapeutic treatment of infectious diarrhea. This work includes the development of novel in vitro and in vivo models for enteric pathogens such as Shigella and clinical pharmacology support for clinical trials investigating novel treatments for enteric infections. In addition to his work on enteric infections, Dr. Arnold is the director of the Bioanalysis and Pharmacokinetics Lab at the University of Washington. This lab supports a variety of internal and external projects using mass spectrometry to quantify small molecules and proteins in complex tissue samples.
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