State-of-the-art on the ADME of Protein Therapeutics | An ISSX 2023 Short Course

This short course, featured during the 25th North American ISSX Meeting in September 2023, is designed to provide the audience with state-of-the-art perspectives on the pharmacokinetics (PK) of protein therapeutics. The first lecture focuses on the mechanisms of clearance, disposition/ biodistribution, and absorption (subcutaneous, oral!) of protein prediction of clinical PK of protein therapeutics. The last talk focuses on how to exploit the knowledge about the determinants for the PK of protein therapeutics to design better/optimal molecules with desired PK and pharmacology.

Basic Tenets for the ADME of Protein Therapeutics
Dhaval Shah, University at Buffalo, Buffalo, New York, USA

In vitro and in vivo Systems for Predicting the ADME of Protein Therapeutics: Are We There Yet?”.
Brooke Rock, Amgen, Inc., South San Francisco, California, USA

Beyond Non-human Primates: Transgenics and PBPK Models for Predicting the Human PK of Protein Therapeutics
Alison Betts, Takeda, Boston, Massachusetts, USA

Engineering Proteins to Achieve Desired ADME Characteristics
Javier Chapparo-Riggers, Pfizer, San Diego, California, USA

Chairs: Dhaval Shah, University at Buffalo, Buffalo, New York, USA and Brooke Rock, Amgen, Inc., Bend, Oregon, USA