Uncooperative Drugs in in vitro Transporter Research: Practical Approaches to Address Instability and Nonspecific Binding Challenges

In vitro drug transporter data are critical for understanding drug-drug interaction potential, but those data are only useful if conclusions can be drawn. Researchers are plagued with practical challenges associated with compounds that are unstable, sticky or insoluble, resulting in convoluted or inconclusive results. Three interesting transporter case studies are presented, each highlighting a creative solution to explore perplexing initial results and generate useful data, despite problematic physicochemical characteristics of the drugs involved.

This webinar is sponsored by BioIVT.