Zonal Hepatic Transporter Distribution in MASH and THC Interactions with Hepatic and Placental Transporters: Implications for Drug Disposition and Response in Specific Populations

Kim L.R. Brouwer, Pharm.D., Ph.D., is the William R. Kenan Jr. Distinguished Professor in the Division of Pharmacotherapy and Experimental Therapeutics at the UNC Eshelman School of Pharmacy, associate dean for research and graduate education, and a professor in the curriculum in toxicology.

Brouwer received her B.S. in pharmacy from Oregon State University. She completed her Pharm.D. at the University of Kentucky (UK) College of Pharmacy in conjunction with a pharmacy residency at the UK Medical Center and a PhD in pharmaceutical sciences/pharmacokinetics. After postdoctoral training (pharmacology/drug metabolism) in the UK College of Medicine, she joined the faculty at the University of North Carolina in 1986, where she served as director of graduate studies for the UNC Eshelman School of Pharmacy from 1996 to 2004, and Chair of the Division of Pharmacotherapy and Experimental Therapeutics from 2004-2015.

Jashvant (Jash) Unadkat, Ph.D. is a Professor in the Dept. of Pharmaceutics at the School of Pharmacy, University of Washington, Seattle.   He received his Bachelor’s degree in Pharmacy (B.Pharm.) from the University of London (1977), his Ph.D. from the University of Manchester and his postdoctoral training at the University of California at San Francisco.  He held the Milo Gibaldi Endowed Professorship in the Department from 2016-21. Dr. Unadkat’s research interests are on mechanisms of transport and metabolism of drugs during pregnancy, and transport of drugs across the placental, hepatic, intestinal and blood-brain barrier.  Dr. Unadkat has published more than 250 peer-reviewed research papers.  He is a fellow of AAAS, AAPS, JSSX, and the founding co-chair (1999-2001) of the focus group of AAPS on Drug Transport and Uptake.  Dr. Unadkat received the AAPS Research Achievement Award in 2012 and the ISSX Scientific Achievement Award in 2023.  Dr.  Unadkat created and led the UW Research Affiliates Program on Transporters (UWRAPT), a cooperative effort between the UW School of Pharmacy and pharmaceutical companies, for 10 years. He also leads UWPKDAP, a NIDA funded Program Project grant (P01) on drug disposition during pregnancy and co-leads UW Transporter Elucidation Center (https://depts.washington.edu/uwtec/) funded by NICHD to identify and characterize novel transporters in the placenta and the developing intestine.  Dr. Unadkat has been an Associate Editor for the Journal of Pharmaceutical Sciences, an Editor of AAPS Journal, and a member of the NIH Pharmacology study section (2000-3).  Dr. Unadkat has organized or co-organized numerous national and international conferences on the role of transporters and pregnancy in the disposition of drugs.