Session 1: Small Molecule Metabolites in Drug Discovery and Development

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Chairs: Aaron Teitelbaum, Bingming Chen, Carley Heck, and Matthew Albertolle

Why Drug Metabolites Can be Important; Examples of Active and Toxic Metabolites 

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Rheem Totah, University of Washington, Seattle, Washington, USA


Modern Method of Metabolite ID: Part 1. HRMS: Instrumentation, Strategies

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Mark Cancilla, Merck & Co., Inc, West Point, Pennsylvania, USA



Modern Method of Metabolite ID: Part 2. 1D and 2D NMR

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Gregory Walker, Pfizer, Groton, Connecticut, USA



Predicting Metabolite Levels From in vitro Data

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Ernie Callegari, Pfizer, Groton, Connecticut, USA




Accessing Metabolites of Various Types – Biosynthesis, Isolation Methods 

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Liz Gillam, University of Queensland 


Roundtable Discussion with Speakers





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Session 1: Small Molecule Metabolites in Drug Discovery and Development
Recorded 03/01/2023  |  60 minutes
Recorded 03/01/2023  |  60 minutes Time Stamps: 0:00 - Welcome and Introduction 6:40 - Rheem Totah's Presentation: The Importance of Drug Metabolites: Examples of Active and Reactive Metabolites 45:37 - Mark Cancilla's Presentation: Implementation of Innovative HRMS Instrumentation Strategies to Help Accelerate Metabolite Identification and Preclinical Drug Discovery 1:34:54 - Greg Walker's Presentation: Modern Method of Metabolite ID: Part 2. 1D and 2D NMR 2:21:20 - Ernesto Callegari's Presentation: Predicting Human Metabolite Levels From in vitro Data 3:03:28 - Elizabeth Gillam's Presentation: Accessing Metabolites of Various Types – Biosynthesis, Isolation Methods 3:38:33 - Bioanalysis in ADME Science and Biotransformation, Mechanisms and Pathways Focus Group Overview 4:00:05 - Panel Discussion
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