Small Molecule Metabolites in Drug Discovery and Development | An ISSX 2023 Virtual Workshop Event
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Register
- Non-member - $400
- Member - $300
- Student - $125
This workshop is organized through the efforts of the ISSX Biotransformation Mechanisms and Pathways Focus Group and is chaired by Carley Heck of Pfizer and Valerie Kramlinger of Vanderbilt University.
This virtual workshop will focus on the impact of small organic molecule metabolism science on both drug discovery and drug development. This three day workshop will dissect the types of in vitro and in vivo drug metabolism studies conducted to support the drug discovery-development pipeline, including the experimental and analytical techniques used and the impact of the data generated. Some of the exciting topics to be covered are: the importance of drug metabolites, analytical techniques of metabolite ID, prediction of human circulating metabolite profiles, metabolite biosynthesis, human ADME study strategies and impact, and both the pharmaceutical industry and regulatory perspectives on the value of human ADME studies and drug metabolism science. Each session of this workshop will feature 4-5 expert speakers, a daily panel discussion, and poster sessions; the latter will be selected from the pool of abstracts from the students and industry attendees.
The workshop includes access to all presentation slides and recordings.
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Contains 1 Component(s)
This virtual workshop will focus on the impact of small organic molecule metabolism science on both drug discovery and drug development.
Chairs: Aaron Teitelbaum, Bingming Chen, Carley Heck, and Matthew Albertolle
Why Drug Metabolites Can be Important; Examples of Active and Toxic Metabolites
Rheem Totah, University of Washington, Seattle, Washington, USAModern Method of Metabolite ID: Part 1. HRMS: Instrumentation, Strategies
Mark Cancilla, Merck & Co., Inc, West Point, Pennsylvania, USA
Modern Method of Metabolite ID: Part 2. 1D and 2D NMR
Gregory Walker, Pfizer, Groton, Connecticut, USA
Predicting Metabolite Levels From in vitro Data
Ernie Callegari, Pfizer, Groton, Connecticut, USA
Accessing Metabolites of Various Types – Biosynthesis, Isolation Methods
Liz Gillam, University of Queensland
Roundtable Discussion with Speakers -
Contains 1 Component(s)
This virtual workshop will focus on the impact of small organic molecule metabolism science on both drug discovery and drug development.
Chairs: Aaron Teitelbaum, Bingming Chen, Carley Heck, and Matthew Albertolle
The Human ADME Study: Comparison of Various Strategies and Technical Approaches
Chandra Prakash, Agios
Accelerator Mass Spectrometry for the Support of Microtracer Studies @ Boehringer-Ingelheim, Technical Aspects of AMS' Deep Dive on How AMS Actually Works
Stefan Blech, Boehringer Ingelheim
Ralf Laux, Boehringer Ingelheim
How to Deal with Metabolites from Human ADME: Part 1. MIST
Yuexia Liang, Merck
Assessing Metabolite Contribution to Target Activity and DDI
Sheila Peters, Boehringer Ingelheim
Roundtable Discussion with Speakers -
Contains 1 Component(s)
This virtual workshop will focus on the impact of small organic molecule metabolism science on both drug discovery and drug development.
Chairs: Faye Vazvaei-Smith, Wenkui Li, Carley Heck, and Scott Obach
Industry Perspective on the Value of ADME Studies and Drug Metabolites
Douglas Spracklin, Pfizer
Drug Metabolites and Their Roles in Drug-drug Interactions
Xinning Yang, U.S. Food and Drug Administration
Vignette 1
Simone Schadt, Roche
Kenichi Umehara, Roche
Vignette 2
Sekhar Surapaneni, Bristol Myers Squibb
Roundtable Discussion with Speakers