Session 1: Small Molecule Metabolites in Drug Discovery and Development


Back to Package

Only available as part of a package

Chairs: Aaron Teitelbaum, Bingming Chen, Carley Heck, and Matthew Albertolle

Why Drug Metabolites Can be Important; Examples of Active and Toxic Metabolites 

image



Rheem Totah, University of Washington, Seattle, Washington, USA


Modern Method of Metabolite ID: Part 1. HRMS: Instrumentation, Strategies

image


Mark Cancilla, Merck & Co., Inc, West Point, Pennsylvania, USA



Modern Method of Metabolite ID: Part 2. 1D and 2D NMR

image

Gregory Walker, Pfizer, Groton, Connecticut, USA



Predicting Metabolite Levels From in vitro Data

image  


Ernie Callegari, Pfizer, Groton, Connecticut, USA




Accessing Metabolites of Various Types – Biosynthesis, Isolation Methods 

image


Liz Gillam, University of Queensland 


Roundtable Discussion with Speakers





Key:

Complete
Failed
Available
Locked
Session 1: Small Molecule Metabolites in Drug Discovery and Development
Recorded 03/01/2023  |  60 minutes
Recorded 03/01/2023  |  60 minutes Time Stamps: 0:00 - Welcome and Introduction 6:40 - Rheem Totah's Presentation: The Importance of Drug Metabolites: Examples of Active and Reactive Metabolites 45:37 - Mark Cancilla's Presentation: Implementation of Innovative HRMS Instrumentation Strategies to Help Accelerate Metabolite Identification and Preclinical Drug Discovery 1:34:54 - Greg Walker's Presentation: Modern Method of Metabolite ID: Part 2. 1D and 2D NMR 2:21:20 - Ernesto Callegari's Presentation: Predicting Human Metabolite Levels From in vitro Data 3:03:28 - Elizabeth Gillam's Presentation: Accessing Metabolites of Various Types – Biosynthesis, Isolation Methods 3:38:33 - Bioanalysis in ADME Science and Biotransformation, Mechanisms and Pathways Focus Group Overview 4:00:05 - Panel Discussion
You must register to access.