This workshop focuses on bioanalytical techniques, including biotransformation (and subsequent bioanalysis) of macromolecules. This workshop provides both content focusing on fundamentals and new and emerging technologies.

The workshop is neither trying to provide a 101 course on LC-MS proteomics nor attempts to focus on what is new in LC-MS proteomics techniques. Attendees need to have some background but not necessarily leading experts in the field. The consensus report from the previous ISSX Workshop held in 2018 (Prasad et al. 2019, Clinical Pharmacology and Therapeutics) is considered a background reading. The recent Symposium Repot from North American ISSX 2023 in Boston (Prasad et al 2024, Drug Metabolism Disposition, In Press) captures the content of lectures and workshop exercises. Hence, the event builds on what is known in the literature in relation to LC-MS proteomics and provides more practical guidance for those who are expanding their research activities in this area, such that they do not go through pitfalls and get to the end point faster.

This virtual workshop will bring together scientists from academia, industry, and regulatory agencies to share their research findings, experience, and expert views on endogenous biomarkers for drug transporters, an active research area with rapid advances in recent years.

This virtual workshop will focus on the impact of small organic molecule metabolism science on both drug discovery and drug development. This three day workshop will dissect the types of in vitro and in vivo drug metabolism studies conducted to support the drug discovery-development pipeline, including the experimental and analytical techniques used and the impact of the data generated. Some of the exciting topics to be covered are: the importance of drug metabolites, analytical techniques of metabolite ID, prediction of human circulating metabolite profiles, metabolite biosynthesis, human ADME study strategies and impact, and both the pharmaceutical industry and regulatory perspectives on the value of human ADME studies and drug metabolism science. Each session of this workshop will feature 4-5 expert speakers, a daily panel discussion, and poster sessions; the latter will be selected from the pool of abstracts from the students and industry attendees.

This virtual workshop will focus on the advancements in the application of PBPK as a mechanistic tool in the discovery and development setting. The workshop has been structured into three sessions with emphasis on emerging trends such as special population, biomarker-informed DDI modeling, and diverse drug development applications. Each session will include lectures and short presentations, the latter will be selected from the pool of abstracts from the students and industry attendees. The workshop includes access to all presentation slides and recordings.

This meeting – under the overarching theme “Broadening Our Horizons”- brought together researchers engaged in drug research and drug development across modalities such as small molecules, (complex) biologics, vaccines, molecules beyond the “rule of five”, peptides, and RNA therapeutics. Throughout the meeting there were plenary lectures by eminent researchers in the field of drug discovery and development on topics such as the development of the COVID-19 vaccine, the economics of the pharmaceutical industry, and membrane protein structure-function analysis using LC-MS.

This workshop brings together scientists from academia, industry, and regulatory agencies in an interactive format to discuss contemporary topics in applied small molecule enzyme and transporter research. We are planning sessions covering not only laboratory and analytical challenges associated with studying enzymes and transporters in vitro, but also challenges and potential solutions/best practices in translation of in vitro ADMET data to in vivo drug disposition and clinical drug-drug interactions (DDIs). The workshop includes access to all presentation slides and recordings.