ISSX Webinars are presented by internationally recognized scientists on a variety of subjects relevant to the field. The ISSX Continuing Education Committee is charged with the responsibility for reviewing these educational offerings and setting the webinar schedule.
When you purchase a webinar registration, you will receive access to speaker slides, the recorded lecture, and the Q&A session.
Cost Effective and Efficient Progression of Lead Drug Candidates to First in Human Studies in Two Largest Economies in the World: USA and China
This webinar is intended to highlight and discuss: The Process of Drug Discovery to Clinic.
Highlights of the in vitro Sections of the Draft ICH Drug Interaction Studies M12 Guideline and Comparison With Current Guidance
This symposium is intended to provide perspectives on the impact that the ICH M12 guideline will have on the in vitro DDI studies required for drug development.
The Significance of Primary Human Hepatic Cells in Drug Development Research and its Utilization in Predictive Applications Using the Millifluidic Liver Tissue Chips
This webinar will highlight how primary human cells play a key role in the performance of Liver Tissue Chips, which are at the forefront of drug development technology. The Liver Tissue Chip, which utilizes primary cells such as human hepatocytes and non-parenchymal cells, represents a significant advancement in the field, offering a promising tool for predicting pharmacokinetic profiles, toxicodynamic assessment and drug safety evaluation in alignment with human physiology.
We Are Not "DON" YET: Discovery of Tumor Targeted Glutamine Antagonists Through Prodrug Strategy | Dr. Rana Rais
This webinar is intended to discuss a prodrug approach to target tumors. Developing tumor targeting prodrugs is highly challenging. There are not many successful examples in the field. Effective screening strategies are much needed to enable identification of successful prodrug candidates. This is a great example to spark some new ideas in the field. The enzymatic processes for prodrug cleavage are unique and the successful screening strategy is highly educational for scientists in the field.
- Contains 3 Component(s) Recorded On: 10/24/2023
The webinar is intended to highlight the efforts in xenobiotic research and translatability to drug development in Africa. Learning Objectives: 1. To explore the gaps in xenobiotics research in Africa and discuss the implications for drug development and healthcare. 2. To highlight the need for comprehensive genomic data collection and representation in Africa, recognizing the continent's genetic diversity and importance in global research and healthcare initiatives.
Uncooperative Drugs in in vitro Transporter Research: Practical Approaches to Address Instability and Nonspecific Binding Challenges
This symposium is intended to provide insights on best practices to address the challenges associated with conducting drug transporter studies with compounds that are unstable, sticky or unstable.
Importance of Target-mediated Drug Disposition (TMDD) of Small-molecule Compounds and its Impact on Drug Development | Dr. Guohua An
This webinar is intended to increase the awareness of TMDD in small molecules and highlight the importance of recognizing TMDD of small-molecule compounds during clinical development.
Clofazimine Pharmacokinetics in HIV-Infected Adults with Diarrhea: Implications of Diarrheal Disease on Absorption of Orally Administered Therapeutics | Dr. Samuel Arnold
This webinar is intended to highlight the potential impact of diarrheal disease on oral drug pharmacokinetics using clofazimine as a case study.
Aldehyde Oxidase: What is Needed to Develop Robust Physiologically-Based Pharmacokinetic Models? | Dr. Sandhya Subash & Dr. Nihan Izat
This webinar will highlight the challenges and limitations for prediction of in vivo clearance for aldehyde oxidase (AO) substrates in human.
Electrophilicity of Pyridazine-3-Carbonitrile, Pyrimidine-2-Carbonitrile, and Pyridine-Carbonitrile Derivatives: A Chemical Model To Describe the Formation of Thiazoline Derivatives in Human Liver Microsomes | Dr. Sarmistha Deb
Mechanistic insights gained from this study could be used to assist a medicinal chemistry campaign to design compounds that were less prone to the formation of reactive metabolites.