This webinar is intended to raise the awareness of complicated scenario where drug-drug-disease interaction occurs and how to evaluate the PK of drugs using PBPK to inform the optimal use of drugs in such patient group.

This webinar is intended to provide education and updates of this evolving area to scientists and graduate students.

The knowledge gained from this presentation will help scientists at all levels to learn about the latest developments in the structure elucidation of key drug transporters, that provide insights into how transporter alterations affect their function and may accelerate the discovery of more effective drugs to either target or evade transporters.

This webinar aims to introduce the use of various tools to elucidate transporter function and consequently, in vivo exposure to transporter substrates. This includes the use of proteomics to inform an efflux ratio-relative expression factor enabling prediction of fetal exposure across the placenta, a novel metabolomics approach to identify biomarkers of renal OAT1/3 and MRP2/4 and lastly, a case study highlighting the importance of elucidating both the pharmacokinetics and pharmacodynamics of a P-gp substrate in determining its efficacy as CNS drug. The present webinar also aims to recognize graduate students and postdoctoral fellows from academia who carried out transporter-related research and presented their work in the form of a poster in 2023 North American ISSX annual meeting.

This webinar aims to introduce various tools/platforms, the use of primary human hepatocyte spheroids, cryo-electron microscopy, and bioengineered microRNA, in drug transporter research and drug discovery.

This webinar aims to highlight current knowledge about albumin-mediated uptake by organic anion transporters expressed in liver and kidney. Special emphasis will be placed on in vitro evidence to support the hypothesis and the complexity confounded by the non-specific binding of the drug-albumin complex. Speakers: Mengyue (Melody) Yin, University of Washington, USA Shawn Pei Feng Tan, University of Manchester, UK Panelists: Aleksandra Galetin, University of Manchester, UK Jash Unadkat , University of Washington, USA Yuichi Sugiyama, Josai International University, Japan

This webinar will address the current state of the science for the SLC16 Monocarboxylate Transporters.

This virtual workshop will bring together scientists from academia, industry, and regulatory agencies to share their research findings, experience, and expert views on endogenous biomarkers for drug transporters, an active research area with rapid advances in recent years.